ChemDraw and ChemOffice+ use AppTranslocation on macOS even when installed in /Applications

As normal on macOS, I have copied the 2 applications (ChemDraw and ChemOffice+) from the disk image to the /Applications folder.(1)

I also use LittleSnitch to authorize network traffic manually.

LittleSnitch informed me that both applications actually run in AppTranslocation (see attached image) which they shouldn't because they are in /Applications. So do they run code from outside that folder?

System: macOS Catalina v10.15.7, iMac 8GB

(1) I have checked that I didn't move them to (tilde)/Applications by mistake